Border Collie Goniodysgenesis Database


22nd March 2014 

Pastoral Breed Health Foundation – What’s been happening?

·Gonioscopy Project – In the U.K. we have been awaiting the figures from the BVA since the Border Collie was put onto schedule B (under investigation) . The following is the reported figures so far and comments from Ian Mason, Chief Panellist for Eye Testing in the U.K.

In the last 12 months 91 Border Collies were reported to have undergone a gonioscopy. One of these showed a severe level of goniodysgenesis and four showed lesser degrees of change. This was a slightly lower percentage of abnormality than noted in the previous years where abnormality was noted in approximately 7% of dogs examined. The percentage of goniodysgenesis seen in breeds where inherited or suspected inherited glaucoma does not occur is much less than this, probably by an order of 10 fold (i.e. a level of 0.5% goniodysgenesis or less).

Tonometry or Intra-ocular pressure measurement can tell you if an animal currently has an abnormal Intra-ocular pressure which if raised is glaucoma, but cannot tell us anything in regard to the presence or absence of goniodysgenesis. It is helpful to diagnose the presence of glaucoma but not the existence of the predisposing problem of goniodysgenesis, which we believe to be the cause of glaucoma in the Border Collie. It is important to realise that the abnormality of goniodysgenesis does not mean glaucoma will occur in all dogs where goniodysgenesis is found. It is an indicator of the pre-disposition to glaucoma development. I trust this of some help to you. Certainly the results indicate that there is a significant level of goniodysgenesis in the Border Collie breed but more examinations need to be carried out before we have knowledge as to the true incidence in this breed.

Taking the numbers from the above, it is clear how important the database is and the need for everyone to include their results – with some simple maths it is clear that we have had cases that have undergone gonioscopy and shown levels of abnormality (failures) that have not been recorded and therefore, as breeders, we are unaware who these dogs are. ·

News on the research – an application has gone in via Roslin Institute for funding on the project and we await the outcome. This would be a great break through in terms of funds to move the research on. · We also have a new researcher appointed to assist on the project and we now have an updated list of dogs where they require additional DNA samples as some of the samples have not provided enough DNA and in some cases not previously requested.

The main issue has been the poor standard of the samples returned to the PBHF from Australia following the death of our researcher Alan Wilton. We have therefore had to request more swabs and/or blood and thank people for their co-operation. ·

A review of the “control group” those not affected has also produce a new “working” list which is now being used. This will result in a closer relationship with those in the breed to help assist the hard job of locating the genes from the DNA. ·

We need everyone to use the database and send in their results and we need swabs sent in of any that are affected  to help the research. Many UK breeders are using the database and assisting and it would be great to have some more entries from overseas and also DNA from the appropriate dogs. If in doubt and you think you can help please contact us.

In order to encourage owners to test and also provide information for the research – the PBHF will assist clubs putting on eye testing sessions where they are offering a discount for the goniocopy test – for example if a club offer to reduce the price by £5 then the  PBHF will match it with another £5 reduction – one dog one owner. We might be able to extend this, so please look out for details or contact one of us. Good news we have extended and are offering £5 reduction at any club show or session authorised by the PBHF.  For contact details please go to the PBHF website

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As of March 2014, The Animal Health Trust in the UK is looking at the genetics of goniodysgenesis and glaucoma in a number of breeds including the Border Collie. We are looking for cheek swab samples from dogs diagnosed for either/both conditions as well as those certified to be clear at the age of 5 or above (by an ophthalmologist). For further information please contact me at James.Oliver@aht.org.uk

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